TABLE 6

Urine conjugated/unconjugated molar ratios of tramadol, M1, M2, and M5 measured 4 hours after administration of tramadol (5 mg/kg b.wt.) orally to 10 dogs (twice), and after pretreatment with fluconazole and placebo, separated by a 2-week washout period

The data are presented as the median and the 25%–75% interquartile range of concentrations. The P value indicates the significance of paired comparisons between fluconazole and placebo treatments using the Wilcoxon signed-rank test.

AnalyteUrine Conjugated/Unconjugated Molar Ratio
PlaceboFluconazole
Median25%–75%Median25%–75%P Value
Tramadol0.014(0.008–0.57)0.002(0.0002–0.022)0.027*
M18.3(4.6–16)2.8(1.1–3.9)0.002*
M20.08(0.01–0.34)0.44(0.20–1.08)0.049*
M51.2(0.5–3.6)1.7(0.7–3.6)0.43
  • * A P-value of less than 0.05 was considered statistically significant.