TABLE 2

Hepatocyte characteristic parameter used for predicting lysosomal accumulation

ParameterValue
VB5.54 ± 0.07 pl
Vlyso0.539 ± 0.001 fl
Nlyso156 ± 4.6
Embedded Image1.49% ± 0.08%
Embedded Image5.53
σ20.1849
pHmin4
pHcyto7.2
  • fl, femtoliter; Embedded Image, lysosomal fraction of cellular volume; Nlyso, number of lysosomes per cell; pHcyto, cytosolic pH; Embedded Image, mean lysosomal pH; pHmin, minimum pH in lysosomes; VB, volume of nonacidic compartment; Vlyso, volume of single lysosome; σ2, variance of mean lysosomal pH.