MRM transitions and major P450 isoforms responsible for metabolism of the 17 test compounds
| Compound | MRM Transition (± mode) | P450 Isoform | HLM Km | References for Km Values |
|---|---|---|---|---|
| μM | ||||
| Riluzole | 235-166(+) | CYP1A2 | 30 | Sanderink et al., 1997 |
| Theophylline | 181-124(+) | 4.5 | Sarkar et al., 1990 | |
| Lidocaine | 235-86 (+) | 1500 | Wang et al., 1999a | |
| Diclofenac | 298-252(+) | CYP2C9 | 22 | Carlile et al., 1999 |
| Glimepiride | 489-364(−) | 0.56 | Maekawa et al., 2009 | |
| Meloxicam | 352-184(+) | 14 | Chesné et al., 1998 | |
| Tolbutamide | 273-155(+) | 14 | Carlile et al., 1999 | |
| Warfarin | 307-250(-) | 0.29 | Ngui et al., 2001 | |
| Voriconazole | 350-281(+) | CYP2C19 | 8.1 | Hyland et al., 2003 |
| Diazepam | 285-193(+) | 180 | Andersson et al., 1994 | |
| Flecainide | 415-301(+) | CYP2D6 | Unknown | Not available |
| Risperidone | 411-191(+) | 0.26 | Yasui-Furukori et al., 2001 | |
| Atomoxetine | 256-148(+) | 2.2 | Ring et al., 2002 | |
| Alprazolam | 309-281(+) | CYP3A4 | 340 | Gorski et al., 1999 |
| Atazanavir | 705-335(+) | Unknown | Not available | |
| Midazolam | 326-291(+) | 7.5 | Wang et al., 1999b | |
| Prednisolone | 361-343(+) | Unknown | Not available |
HLM, human liver microsomes; MRM, multiple reaction monitoring.