TABLE 2

Scaling parameters to calculate CLint or CLh

ModelHepatoPacSuspended Hepatocytes
Maximum incubation time, h (min)168 (10,080)6 (360)
Hepatocytes per well3,35050,000
Incubation volume (ยตl)6450
In vivo (hepatocyte), (n per g liver)120,000,000
Liver weight (g)1800
Average body weight (kg)70
Liver blood flow (ml/min per kg)21