^b The in vivo clearance value reported for extensive metabolizers was used since the incidence of this phenotype is highest in the population. N.D., Not determined. Predicted CL_h values for both corrected (CL_{h,w/f u}) and not corrected (CL_{h, w/o/f u}) for plasma protein binding werederived from the average of at least 2 replicates. Values that are highlighted in green are within 2-fold of the in vivo CL _non-renal; values that arehighlighted in yellow are within 3-fold of the in vivo CL_non-renal; values that are highlighted in red are outside 3-fold of the in vivo CL_non-renal.Categorization of fold prediction was defined as follows for ± 2-fold, 0.45 ≤ value ≤ 2.1; ± 3-fold, 0.325 ≤ value ≤ 3.1.