Summary of the mean total recovery of radioactivity 0–96 hours after an oral dose of [14C]acalabrutinib to male and female rats and dogs and the geometric mean 0–168 hours after an oral dose to male and female human subjects expressed as a percentage of administered dose
Values are presented as means ± S.D. and geometric means (%CV).
| Type of Sample | Administered Dose Recovered | ||||
|---|---|---|---|---|---|
| Rat | Dog | Human | |||
| Male (n = 3) | Female (n = 3) | Male (n = 3) | Female (n = 3) | Overall (n = 6) | |
| % | |||||
| Urine | 2.7 ± 0.8 | 3.6 ± 0.3 | 15.2 ± 1.4 | 14.6 ± 3.0 | 12.0 (15.9) |
| Feces | 91.2 ± 6.0 | 88.3 ± 3.6 | 71.8 ± 0.7 | 69.3 ± 7.9 | 83.5 (5.1) |
| Cage rinse | 0.2 ± 0.03 | 0.8 ± 0.4 | 2.5 ± 0.9 | 1.6 ± 1.9 | NA |
| Carcass | 0.7 ± 0.1 | 1.0 ± 0.5 | NA | NA | NA |
| Total | 96.8 ± 3.5 | 94.3 ± 2.6 | 91.1 ± 0.5 | 87.5 ± 6.3 | 95.7 (4.5) |
NA, not applicable.