TABLE 1

Estimates of TVP and DM-4103 + DM-4107 clearance values in IPLs from WT and PCK rats based on the model scheme depicted in Fig. 1

Livers were perfused with TVP (∼7 μM) and subsequently with blank buffer (washout) for 30 min each. Statistically significant differences were based on nonoverlapping 95% confidence intervals (CI): *P < 0.05, PCK vs. WT; #P < 0.05, CLBL vs. CLBile within the same rat IPL group; P < 0.05, compared with CLMet within the same rat IPL group.

ParameterEstimate (CV%); [95% CI]
WTPCK
CLBL (l/h)0.20 (20%); [0.12, 0.28]#,†0.29 (22%); [0.16, 0.43]#,†
CLUP (l/h)21 (14%); [15, 26]29 (14%); [21, 38]
CLBile (l/h)0.11 × 10−3 (10%); [0.85 × 10−4, 0.13 × 10−3]*,#,†0.49 × 10−4 (16%); [0.33 × 10−4, 0.65 × 10−4]*,#,†
CLMet (l/h)0.44 × 10−1 (4.2%); [0.40 × 10−1, 0.48 × 10−1]0.38 × 10−1 (8.9%); [0.31 × 10−1, 0.45 × 10−1]
CL03,07 (l/h)0.18 × 10−2 (20%); [0.10 × 10−2, 0.26 × 10−2]0.47 × 10−2 (39%); [0.99 × 10−3, 0.85 × 10−2]
CLBL,03,07 (l/h)0.50 × 10−2 (24%); [0.26 × 10−2, 0.74 × 10−2]0.91 × 10−2 (43%); [0.11 × 10−2, 0.17 × 10−1]
CLBile,03,07 (l/h)0.16 × 10−2 (23%); [0.84 × 10−3, 0.24 × 10−2]0.11 × 10−2 (76%); [−0.62 × 10−3, 0.28 × 10−2]
KLag,Bile (h−1)17 (15%); [12, 22]
KLag,Bile,03,07 (h−1)4.1 (21%); [2.3, 5.8]