Observed and allometric scaling of primary pharmacokinetic parameters of cefadroxil
Plasma concentration-time profiles were fit to a two-compartment disposition model in mice after an 11 nmol/g (4 mg/kg) intravenous bolus dose of cefadroxil (Hu and Smith, 2016). For the total plasma clearance, K10 = CL/V1. For the clearance between the central and peripheral compartments, CLD = CL12 = CL21, K12 = CL12/V1, and K21 = CL21/V2.
| Parameter | Mouse (Observed) | CV | Mouse (Optimized) | Error | Human (Predicted) |
|---|---|---|---|---|---|
| % | % | ||||
| CL (l/h per kilogram) | 0.92 | 10.5 | 0.88 | -4.3 | 0.079 |
| CLD (l/h per kilogram) | 0.38 | 29.8 | 0.041 | ||
| V1 (l/kg) | 0.18 | 20.6 | 0.16 | -15.5 | 0.063 |
| V2 (l/kg) | 0.31 | 42.9 | 0.122 |
CLD, clearance between the central and peripheral compartments; V1, volume of distribution in the central compartment; V2, volume of distribution in the peripheral compartment.