TABLE 3

Allometric scaling of cefadroxil P_eff to humans when estimated by the in situ permeability of small and large intestines from WT and humanized PepT1 mice

Intestinal segments include duodenum, jejunum, ileum, and ascending colon. The P_eff values of cefadroxil in humans were predicted after single oral doses of 5, 15, and 30 mg/kg, after 500 mg (6.7 mg/kg) oral doses every 6 hours, and after the drug-drug interaction of 5 mg/kg cefadroxil plus 45 mg/kg cephalexin. The intestinal permeability (P_eff) is in units of centimeter/second (×10⁻⁴). The method for obtaining these values is described in the Supplemental Material.