Population analysis for multiple dosing regimen of 500 mg (6.7 mg/kg) cefadroxil administered orally every 6 hours in human subjects when estimated by the intestinal permeability from huPepT1 mice
Observed values were obtained from the literature (Santella and Henness, 1982).
| Parameter | Observed | Segmental Peff | Jejunal Peff | ||||
|---|---|---|---|---|---|---|---|
| Predicted | CV | Error | Predicted | CV | Error | ||
| % | % | % | % | ||||
| Cmax (μg/ml) | 15.9 | 19.5 | 26.3 | 22.9 | 19.5 | 26.3 | 22.4 |
| AUC0–t (μg⋅h/ml) | 223 | 225 | 31.3 | −1.0 | 237 | 34.0 | 4.2 |