TABLE 4

Comparison of predicted and observed pharmacokinetic parameters of cefadroxil in humans when estimated by in silico and allometric scaling methods of in situ intestinal permeability from WT and humanized PepT1 mice

The P_eff values are based on the jejunal permeability and the segmental permeabilities of the duodenum, jejunum, ileum, and colon. The observed values were obtained from the literature (Garrigues et al., 1991).

Dose	P_eff Method	C_max (μg/ml)			AUC_0–t (μg⋅h/ml)
Dose	P_eff Method	Observed	Predicted	Error	Observed	Predicted	Error
mg/kg				%			%
5	In Silico	14.7	7.1	−51.7	45.5	28.4	−37.5
	Rat Jej	14.7	7.2	−51.1	45.5	28.7	−36.8
	WT Seg	14.7	30.2	106	45.5	55.1	21.1
	WT Jej	14.7	30.7	109	45.5	55.6	22.3
	hu Seg	14.7	19.1	29.8	45.5	49.2	8.3
	hu Jej	14.7	18.6	26.4	45.5	50.5	11.0
15	WT Seg	33.9	71.8	112	126	158	25.4
	WT Jej	33.9	73.7	117	126	163	29.5
	hu Seg	33.9	37.1	9.5	126	119	−5.2
	hu Jej	33.9	37.6	10.9	126	125	−0.4
30	WT Seg	53.8	110	104	239	287	20.1
	WT Jej	53.8	91.0	69.0	239	307	28.6
	hu Seg	53.8	53.0	−1.5	239	196	−17.8
	hu Jej	53.8	56.2	4.5	239	209	−12.6

hu, humanized; Jej, jejunum; Seg, segment.