TABLE 1

Age dependency of brain uptake of CIS and TRANS uptake is represented as pmol CIS or TRANS/g brain

Data are expressed as mean ± S.D. (n = 3–5). Values in parentheses are multiples of PND 90 values.

IsomerµMPND 15PND 21PND 90
CIS153 ± 6*,# (5.4)23 ± 5* (2.4)10 ± 1
CIS10498 ± 70*,# (3.7)188 ± 24 (1.4)136 ± 22
CIS502044 ± 415*,# (3.1)900 ± 218 (1.4)666 ± 55
TRANS152 ± 15*,# (5.5)24 ± 5 (2.5)10 ± 1
TRANS10405 ± 65*,# (3.7)146 ± 16 (1.3)110 ± 9
TRANS501918 ± 632*,# (3.8)754 ± 146 (1.5)510 ± 80
  • * Denotes significant difference from adults (P < 0.05).

  • # Denotes significant difference from PND 21 animals (P < 0.05).