Age dependency of brain uptake of CIS and TRANS uptake is represented as pmol CIS or TRANS/g brain
Data are expressed as mean ± S.D. (n = 3–5). Values in parentheses are multiples of PND 90 values.
| Isomer | µM | PND 15 | PND 21 | PND 90 |
|---|---|---|---|---|
| CIS | 1 | 53 ± 6*,# (5.4) | 23 ± 5* (2.4) | 10 ± 1 |
| CIS | 10 | 498 ± 70*,# (3.7) | 188 ± 24 (1.4) | 136 ± 22 |
| CIS | 50 | 2044 ± 415*,# (3.1) | 900 ± 218 (1.4) | 666 ± 55 |
| TRANS | 1 | 52 ± 15*,# (5.5) | 24 ± 5 (2.5) | 10 ± 1 |
| TRANS | 10 | 405 ± 65*,# (3.7) | 146 ± 16 (1.3) | 110 ± 9 |
| TRANS | 50 | 1918 ± 632*,# (3.8) | 754 ± 146 (1.5) | 510 ± 80 |