TABLE 4

Cannabinoid f_m values in HLMs adjusted for inhibitor cross-inhibition

Data shown are mean ± S.D. of the f_m values from Table 1 adjusted for inhibitor cross-inhibition (P450 enzymes from Table 2 and UGT enzymes from Table 3) using eq. 6.

Enzyme	THC Depletion	11-OH-THC
Enzyme	THC Depletion	Formation	Depletion
CYP2C9	0.82 ± 0.08	0.99 ± 0.10	0.09 ± 0.05
CYP3A	Negligible^{^a}	Negligible^{^a}	0.20 ± 0.08
CYP2C19	Negligible^{^a}	0.07 ± 0.18	Negligible^{^b}
CYP2D6	0.17 ± 0.15	0.24 ± 0.22	Negligible^{^b}
UGT2B7	Negligible^{^c}	N/A^{^d}	0.45 ± 2.78
UGT1A9	Negligible^{^c}	N/A^{^d}	0.22 ± 2.65

N/A, not applicable.
↵^a The f_m values are set to negligible because the adjusted fm result was negative (THC depletion fm: CYP3A = −0.12 ± 0.16, CYP2C19 = −0.53 ± 0.19; 11-OH-THC formation fm: CYP3A = −0.48 ± 0.19).
↵^b No significant inhibition of 11-OH-THC depletion observed in the presence of omeprazole and quinidine.
↵^c No observed depletion of THC by UGT enzymes.
↵^d Not applicable since UGT enzymes did not form 11-OH-THC.