Parameter | Uncorrected Prediction | Corrected Prediction Using a Scaling Factor | |||||
---|---|---|---|---|---|---|---|
Total Human Dataset | Human Drugs Common to Rats | Rat Average (ESFav) | Rat Individual Drug (ESFsd) | Rat Segregated Average (ESFseg) | Rat Segregated Average × Human/Rat Ratio (Human ESFav/Rat ESFav) | Human Segregated Average (ESFseg) | |
Rats, n of drugs | N/A | 23 | 128 | 23 | 128 | 128 | 128 |
Humans, n of drugs | 101 | 23 | 101 | 23 | 101 | 101 | 101 |
GMFE | 4.20 | 4.35 | 0.896 | 3.82 | 2.82 | 0.802 | 1.00 |
RMSE | 3550 | 1000 | 3530 | 1010 | 3030 | 2100 | 1990 |
% within 2-fold | 22.8 | N/A | 35.6 | 13.0 | 30.7 | 45.5 | 49.5 |
Figure | 1A | N/A | 1C | 1E | 6A | 6C | 6E |
N/A, not applicable.