TABLE 3
Segregated scaling factors for rat and human hepatocytes as given by log observed/predicted CL
int
Species
Log average Observed/Predicted for Segregated Observed CL
int
<10
10–100
100–1000
1000–10,000
>10,000
ml/min/kg
Human
0.609
3.94
7.14
22.2
1150
Rat
0.125
1.57
3.24
7.17
179
Human/rat
4.88
2.50
2.20
3.10
6.46