A comparison of the fold-changes (R) in pharmacokinetic parameters of CYP2C8 substrates (given in single doses) caused by gemfibrozil and clopidogrel in the present study and previous publications
Data are either arithmetic or geometric mean ratios with 90% or 95% confidence intervals (CI), or ranges.
| Victim Drug and Its Dose | Clopidogrel 300 mg followed by 75 mg QD Ratio (R) to Placebo (90% or 95% CI, or range) | Gemfibrozil 600 mg BID Ratio (R) to Placebo (90% or 95% CI, or Range) | ||||
|---|---|---|---|---|---|---|
| AUC0–∞R | CmaxR | Reference | AUC0–∞R | CmaxR | Reference | |
| Dasabuvir | ||||||
| 250 mg | 4.7 (90% CI = 3.2–6.7) | 1.6 (90% CI = 1.0–2.6) | Itkonen et al. (2019) | 11.3 (90% CI = 9.1–14) | 2.0 (90% CI = 1.7–2.4) | Menon et al. (2015) |
| Desloratadine | ||||||
| 5 mg | 2.8 (90% CI = 2.3–3.4) | 1.7 (90% CI = 1.3–2.0) | Present study | 4.6 (90% CI = 3.5–6.2) | 1.7 (90% CI = 1.4–2.2) | Present study |
| Montelukast | ||||||
| 10 mg | 2.0 (90% CI = 1.7–2.3) | 1.0 (90% CI = 0.8–1.2) | Itkonen et al. (2018) | 4.4 (95% CI = 3.8–5.0) | 1.5 (95% CI = 1.3–1.8) | Karonen et al. (2010) |
| 4.3 (95% CI = 2.9–6.3) | 1.5 (95% CI = 0.9–2.3) | Karonen et al.(2012) | ||||
| Pioglitazone | ||||||
| 1 mg | 2.0 (95% CI = 1.6–2.5)a | Not reported | Kim et al. (2016) | |||
| 15 mg | 2.1 (90% CI = 1.8–2.6) | 1.0 (90% CI = 0.8–1.4) | Itkonen et al. (2016) | 3.2 (Range = 2.3–6.5) | 1.1 (Range = 0.5–2.6) | Jaakkola et al. (2005) |
| 30 mg | 3.4 (Range = 2.3–6.2) | Not reported | Deng et al.(2005) | |||
| Repaglinide | ||||||
| 0.1 mg | 3.1 (95% CI = 2.1–4.1)b | Not reported | Kim et al. (2016) | |||
| 0.25 mg | 5.1 (90% CI = 3.9–6.6) | 2.5 (90% CI = 1.8–3.5) | Tornio et al. (2014) | 8.1 (Range = 5.5–15) | 2.4 (Range = 1.7–6.1) | Niemi et al. (2003) |
| 3.9 (90% CI = 2.9–5.3)c | 2.0 (90% CI = 1.3–3.1)c | Tornio et al. (2014) | 7.0 (Range = 2.9–14) | 2.2 (Range = 1.4–2.9) | Tornio et al. (2008) | |
| 7.6 (Range = 4.2–12) | 2.7 (Range = 1.5–3.7) | Backman et al. (2009) | ||||
| 7.0 (90% CI = 6.0–8.1) | 2.0 (90% CI = 1.6–2.5) | Honkalammi et al. (2012) | ||||
AUC0–8h, area under the plasma concentration –time curve from 0 to 8 hours; AUC0–24h, area under the plasma concentration–time curve from 0 to 24 hours; AUC0–∞, area under the plasma concentration–time curve from time 0 to infinity.
↵a AUC0–24 h ratio.
↵b AUC0–8 h ratio.
↵c Effect on day 3 of treatment with clopidogrel 300 mg on day 1 followed by 75 mg QD.