TABLE 2

Data from Poulin et al. (2017) and Bounakta et al. (2018) also supporting the trends seen with a transporter-induced protein binding shift

CompoundfupKm 
[ALB] = 0 g/literKm [ALB] = 30 g/lKm,u = Km · fu,p [ALB] = 30 g/literKm,u Fold DifferenceVmax (nmol/min per mg) [ALB] = 0 g/literVmax () [ALB] = 30 g/liyerVmax Fold Difference
μMμMnmol/min per mgnmol/min per mg
Bisphenol A0.04513.43.50.1683.88.01.36.2
Naproxen0.1298.9174.420.94.732.92.21.3