TABLE 3

Pharmacokinetic parameters in TKO mice

The values were larger than the half-life in plasma because complete elimination phase was not captured in the experiments.

UnitAEE788AfatinibAZD3759DacomitinibErlotinibGefitinibOsimertinibVandetanib
thalfh17.65.952.758.990.8464.202.245.74
Apparent CLml/h/kg5316791598822157014311657614
Apparent Vdml/kg13,5025827634910,6671916868053535085
thalf, brainh5.110.52.3216.60.954.763.5941.8a
AUClast, plasmah*ng/ml85812796178776096585661442
S.E._AUClast, plasmah*ng/ml61.823495.913549.795.381.698.7
AUClast, brainh*ng/ml15993082163385721241449891310,773
S.E._AUClast, brainh*ng/ml89.117472.03076.1257.01584563
  • Apparent CL, apparent clearance (CL/F); Apparent Vd, apparent volume of distribution (Vd/F); AUClast, brain, area under the curve from zero to the time of last measured concentration in brain; AUClast, plasma, area under the curve from zero to the time of last measured concentration in plasma; S.E._AUClast, brain, standard error of an estimate of area under the curve in brain; S.E._AUClast, plasma, standard error of an estimate of area under the curve in plasma; thalf, brain, half-life of a drug in brain; thalf, half-life of a drug in plasma.

  • a The half-life was determined by the slope of last three time points in concentration-time profile.