TABLE 2

Fu,hep for 36 compounds across five species

A, B, N, and Z correspond to acid, base, neutral, and zwitterionic compound classes, respectively. Values represent a mean of duplicate determinations.

CompoundClassLogDMouseRatDogMonkeyHuman
BumetanideA−0.0801.00.940.930.971.0
CefazolinA−4.40.971.01.00.931.0
CefoperazoneA−1.10.140.150.18ND0.15
DiclofenacA1.40.840.950.650.720.97
FluvastatinA−2.20.420.580.520.510.53
GemfibrozilA1.71.01.01.01.01.0
GlyburideA1.11.01.00.690.800.84
KetoprofenA−0.160.981.01.01.01.0
NaproxenA0.350.890.991.01.01.0
OxaprozinA0.0901.01.01.01.01.0
PhenytoinA−0.711.00.960.760.480.99
TenoxicamA−2.91.01.01.01.00.93
AmiodaroneB5.90.00230.00810.00600.00620.12
AmitriptylineB2.70.190.240.340.310.32
BupivacaineB2.90.850.960.920.920.94
ChlorpromazineB3.20.0550.140.120.140.17
ClozapineB3.50.330.500.450.450.50
DisopyramideB−0.0701.00.980.971.00.99
HaloperidolB2.90.510.760.700.810.81
ImatinibB2.50.360.790.720.670.79
ImipramineB2.40.340.370.420.330.37
MetoprololB−0.470.920.951.01.01.0
NicardipineB4.60.0380.0620.0510.0340.076
PropranololB0.790.710.690.860.940.82
AlbendazoleN3.00.550.700.680.690.74
AntipyrineN0.440.981.00.891.01.0
DexamethasoneN−4.60.820.950.960.950.95
IndapamideN3.70.140.150.18ND0.15
IsradipineN2.00.220.340.340.320.43
ZidovudineN0.0501.01.00.980.940.97
DoxorubicinZ−1.50.0230.0860.0310.110.11
LevofloxacinZ−0.390.940.980.970.990.98
MethotrexateZ−5.11.01.01.01.01.0
NaltrexoneZ1.60.900.980.981.00.99
TelmisartanZ3.490.400.540.470.440.44
TopotecanZ−0.320.870.730.810.900.71