TABLE 1

Michaelis-Menten kinetic parameters for the oxidative deamination of emixustat in human sources of VAP-1

Test SystemKMVmax
µMpmol/min/mg protein
rhVAP-113.32550
hUCMa14.7 ± 1.70309 ± 176
hAMa15.6 ± 7.1867.6 ± 7.98
hP43433.4
  • a Mean ± S.D. of n = 3 different occasions, each in triplicate.