Component | Urine | Feces | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
0–240 h | 240–1680 h | 0–1680 h | 0–240 h | 240–1680 h | 0–1680 h | |||||
% Inj | % Dose | % Inj | % Dose | % Dose | % Inj | % Dose | % Inj | % Dose | % Dose | |
M2 | 0.6 | 0.17 | 0.2 | 0.07 | 0.23 | |||||
M3 | 3.5 | 0.98 | 4.8 | 1.75 | 2.73 | 7.9 | 0.62 | 8.3 | 1.35 | 1.97 |
M4 | 44.6 | 12.53 | 51.5 | 18.59 | 31.12 | 8.8 | 0.69 | 10.4 | 1.69 | 2.38 |
M8 | 2.2 | 0.61 | 0.8 | 0.29 | 0.90 | 2.5 | 0.20 | 1.2 | 0.19 | 0.39 |
M9 | 1.0 | 0.29 | 0.6 | 0.21 | 0.50 | 20.5 | 1.61 | 11.6 | 1.88 | 3.49 |
M10 | Trace | Trace | Trace | Trace | Trace | |||||
M11 | 2.4 | 0.66 | 1.2 | 0.45 | 1.11 | |||||
M12 + M13 + M14 | 8.4 | 2.35 | 6.6 | 2.38 | 4.73 | 11.1a | 0.87a | 23.4a | 3.79a | 4.67a |
M15 | 3.0 | 0.84 | 2.0 | 0.71 | 1.54 | Trace | Trace | Trace | Trace | Trace |
M17 | Trace | Trace | Trace | Trace | Trace | Trace | Trace | Trace | Trace | Trace |
M18 | 0.5 | 0.14 | 0.4 | 0.13 | 0.27 | 4.2 | 0.33 | 3.5 | 0.57 | 0.90 |
M19 | 11.7 | 3.29 | 5.6 | 2.02 | 5.31 | 2.5 | 0.20 | 1.3 | 0.21 | 0.41 |
M20 | 7.7 | 2.17 | 13.0 | 4.68 | 6.85 | 1.4 | 0.11 | 1.1 | 0.17 | 0.29 |
M21 + M22 | 3.2 | 0.91 | 4.2 | 1.53 | 2.44 | |||||
Unchanged drug | 3.3 | 0.92 | 0.8 | 0.28 | 1.20 | 11.5 | 0.91 | 3.9 | 0.64 | 1.54 |
Sum of reported entities | 92.0 | 25.9 | 91.2 | 33.0 | 58.8 | 70.5 | 5.5 | 64.8 | 10.5 | 16.0 |
Sum of observed metabolites (dose %) | 28.1 | 36.1 | 64.2 | 7.9 | 16.2 | 24.1 |
% Dose, percentage of oral dose; % Inj, percentage of 14C injected onto the HPLC column.
↵a Includes M13 + M14 only.