Substrate | Rate Constants | MAM | Dead model | MM |
---|---|---|---|---|
Liters/min | ||||
O6BG | k3 | 21.955 | 16.154 | 6.896 |
k4 | 0.025 | 0.016 | — | |
k5 | 7.003 | — | — | |
DACA | k3 | 23.282 | 20.353 | 6.307 |
k4 | 0.020 | 0.025 | — | |
k5 | 3.577 | — | — | |
Zaleplon | k3 | 6.248 | 3.387 | 1.660 |
k4 | 0.044 | 0.013 | — | |
k5 | 2.152 | — | — | |
Phthalazine | k3 | 167.355 | 79.953 | 4.403 |
k4 | 0.489 | 0.246 | — | |
k5 | 5.195 | — | — | |
BIBX1382a | k3 | 5.971 | 2.673 | 1.679 |
k4 | 0.070 | 0.012 | — | |
k5 | 2.157 | — | — | |
Zoniporidea | k3 | 0.412 | 0.412 | 0.400 |
k4 | −0.0002 | 0.0005 | — | |
k5 | 1.825 | — | — |
DACA, N-(2-dimethylamino)ethyl)acridine-4-carboxamide; MAM, modulated activity model; MM, Michaelis-Menten; O6BG, O6-benzylguanine.
↵a Rate constants are based on peak area ratio (PAR).