Parameter | Dog (n = 8) | Human (n = 9) | ||
---|---|---|---|---|
[14C]Fasiglifam | [14C]Fasiglifam-G | [14C]Fasiglifam | [14C]Fasiglifam-G | |
Recoverya at 1000 μg/ml (%) | 91.6–96.7 | 98.5–102 | 92.9–99.9 | 91.7–98.0 |
Recoverya at 3000 μg/ml (%) | 80.5–90.6 | 92.0–103 | 63.9–96.4 | 60.3–96.1 |
Recoverya at 10,000 μg/ml (%) | 63.3–77.5 | 55.0–102 | 20.6–78.1 | 24.3–80.2 |
pH | 6.8–7.8 | 6.4–7.6 | ||
Total bile acid concentration (mmol/l) | 119–187 | 11.6–139 |
↵a Recovery of the spiked radioactive material.