TABLE 8

The in vitro solubility of [14C]fasiglifam and [14C]fasiglifam-G, pH, and total bile acid concentrations in dog bile

Values represent the range for eight dogs and nine humans.

ParameterDog (n = 8)Human (n = 9)
[14C]Fasiglifam[14C]Fasiglifam-G[14C]Fasiglifam[14C]Fasiglifam-G
Recoverya at 1000 μg/ml (%)91.6–96.798.5–10292.9–99.991.7–98.0
Recoverya at 3000 μg/ml (%)80.5–90.692.0–10363.9–96.460.3–96.1
Recoverya at 10,000 μg/ml (%)63.3–77.555.0–10220.6–78.124.3–80.2
pH6.8–7.86.4–7.6
Total bile acid concentration (mmol/l)119–18711.6–139
  • a Recovery of the spiked radioactive material.