Concentrations of radioactivity in the plasma and liver after administration of a single oral dose of [14C]fasiglifam in rats and dogs
Data were obtained from one animal for each collection time.
Species | Dose | Time | Concentration of Radioactivity (ยตg Eq/ml or g) | |
---|---|---|---|---|
Plasma | Liver | |||
mg/kg | h | |||
Rat | 2 | 1 | 4.98 | 18.1 |
2 | 8 | 3.32 | 13.8 | |
200 | 1 | 237 | 275 | |
200 | 8 | 352 | 341 | |
Dog | 2 | 2 | 5.04 | 10.6 |
2 | 8 | 1.84 | 5.08 | |
200 | 2 | 315 | 179 | |
200 | 8 | 39.0 | 55.3 |