TABLE 7

Range of bile flow rates and pH values (triplicate samples) after a single dose of [14C]fasiglifam

[14C]fasiglifam was administered intraduodenally to rats and orally to dogs. The pH of the bile was obtained from 0 to 24 h postdose in rats and at 2 and 8 h postdose in dogs. The published bile flow rate is 90 ml/day per kilogram in rats and 12 ml/day per kilogram in dogs (Davies and Morris, 1993).

SpeciesBile Flow Rate (ml/day per kilogram) (n = 2)pH (n = 1)
Vehicle2 mg/kg200 mg/kg2 mg/kg200 mg/kg
Rat44–4961–6892–1157.4–7.77.4–8.0
Dog12–131220–246.5–6.86.8