Range of bile flow rates and pH values (triplicate samples) after a single dose of [14C]fasiglifam
[14C]fasiglifam was administered intraduodenally to rats and orally to dogs. The pH of the bile was obtained from 0 to 24 h postdose in rats and at 2 and 8 h postdose in dogs. The published bile flow rate is 90 ml/day per kilogram in rats and 12 ml/day per kilogram in dogs (Davies and Morris, 1993).
Species | Bile Flow Rate (ml/day per kilogram) (n = 2) | pH (n = 1) | |||
---|---|---|---|---|---|
Vehicle | 2 mg/kg | 200 mg/kg | 2 mg/kg | 200 mg/kg | |
Rat | 44–49 | 61–68 | 92–115 | 7.4–7.7 | 7.4–8.0 |
Dog | 12–13 | 12 | 20–24 | 6.5–6.8 | 6.8 |