TABLE 3

Uptake of [14C]fasiglifam and [3H]pravastatin into rat and dog hepatocytes and the inhibitory effect of cyclosporin A

CompoundConcentrationUptake Clearance (μl/min per miligram protein)
RatDog
Rs704RS740DB252DB268
μmol/l
Pravastatin0.315.819.94.82.7
Pravastatin + CyA0.3 + 102.83.20.70.9
Fasiglifam0.3689.6858.6586.8522.6
Fasiglifam + CyA0.3 + 10632.8715.2556.2421.8
  • CyA, cyclosporin A.