Inhibitors | Caffeine (Paraxanthine) | Debrisoquine (4-OH Debrisoquine) | Tolbutamide (OH-Tolbutamide) | Midazolam (1-OH-Midazolam) | ||||
---|---|---|---|---|---|---|---|---|
HLM | 8HUM | HLM | 8HUM | HLM | 8HUM | HLM | 8HUM | |
Furafylline (CYP1A2) | 53 ± 6* | 56 ± 13* | 65 ± 9 | 91 ± 13 | 103 ± 25 | 63 ± 19 | 95 ± 8 | 92 ± 7 |
Enoxacin (CYP1A2) | 58 ± 15* | 52 ± 8* | 82 ± 29 | 89 ± 13 | 72 ± 27 | 73 ± 13 | 99 ± 13 | 90 ± 4 |
Fluconazole (CYP2C9/CYP3A4) | 114 ± 37 | 100 ± 31 | 96 ± 9 | 88 ± 19 | 35 ± 21* | 41 ± 33* | 29 ± 4*** | 42 ± 5*** |
Sulfaphenazole (CYP2C9) | 78 ± 26 | 67 ± 15 | 79 ± 25 | 88 ± 36 | 14 ± 4** | 28 ± 15** | 107 ± 21 | 125 ± 41 |
Quinidine (CYP2D6) | 105 ± 28 | 74 ± 7 | 22 ± 5* | 43 ± 5* | 75 ± 17 | 132 ± 29 | 83 ± 9 | 97 ± 18 |
Paroxetine (CYP2D6) | 66 ± 26 | 95 ± 22 | 52 ± 11* | 13 ± 5** | 113 ± 50 | 117 ± 34 | 91 ± 8 | 109 ± 17 |
Ketoconazole (CYP3A4) | 135 ± 45 | 85 ± 34 | 142 ± 42 | 152 ± 11 | 154 ± 66 | 92 ± 11 | 6 ± 2*** | 11 ± 2*** |
↵* P < 0.05, **P < 0.01, ***P < 0.001, compared with no inhibitor; unpaired t test, two-tailed P values;