Applications of the 8HUM mouse

Define the role of cytochrome P450s in vivo drug/xenobiotic disposition (CypC4 KO)
Improve the predictive power of drug efficacy studies with more human-like PK and in vivo generation of human drug metabolites
More accurate predictions of individual patient responses to targeted anticancer drugs
Understanding how variability in P450 isozymes affects drug efficacy
Potential application in the study of drug-induced toxicity
Predicting potential drug-drug interactions for single and complex drug mixtures and how these could be circumvented
Studying the interaction of drugs with herbal medicines and environmental agents
Defining PK/PD relationships for chemopreventive agents
Improve in silico algorithms for extrapolating laboratory data to the clinic