Applications of the 8HUM mouse
| Define the role of cytochrome P450s in vivo drug/xenobiotic disposition (CypC4 KO) |
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| Improve the predictive power of drug efficacy studies with more human-like PK and in vivo generation of human drug metabolites |
| More accurate predictions of individual patient responses to targeted anticancer drugs |
| Understanding how variability in P450 isozymes affects drug efficacy |
| Potential application in the study of drug-induced toxicity |
| Predicting potential drug-drug interactions for single and complex drug mixtures and how these could be circumvented |
| Studying the interaction of drugs with herbal medicines and environmental agents |
| Defining PK/PD relationships for chemopreventive agents |
| Improve in silico algorithms for extrapolating laboratory data to the clinic |