TABLE 3

Effect of St. John’s Wort and hyperforin on dabrafenib clearance in the 8HUM mouse

Animal treatments and enzyme activity measurements were carried out as described in Materials and Methods. Data shown are mean ± S.D. from a minimum of three determinations.

VehicleSt. John’s WortHyperforin
Cmax (μg/ml)16.7 ± 2.910.2 ± 1.9**10.9 ± 1
Terminal half-life (h)1.9 ± 1.221.8 ± 0.91.2 ± 0.1
AUCinf(obs) (h*μg/ml)76 ± 3.224.2 ± 3.3****26.7 ± 5.2***
CL/F(obs) (ml/h per kilogram)132 ± 5.5419 ± 58****383 ± 76**
Total hepatic P450 (pmol/mg protein)286 ± 39314 ± 80276 ± 28
n442
  • ** P < 0.01, ***P < 0.001, ****P < 0.0001 for vehicle vs. SJW or hyperforin, t test.