Characteristics of the S 55746 compound
| Parameters | Mouse | Rat | Dog | Human | |
|---|---|---|---|---|---|
| Drug-dependent parameters | |||||
| pKa | Acidic: 9.7/Base: 6.9 | ||||
| Log P | 4.4 | ||||
| Molecular weight (g/mol) | 710.8 | ||||
| PCaco-2 (106 cm/s) | 5.00 | ||||
| Species-dependent parameters (%) | |||||
| fu,p | 1.50 | 2.77 | 1.78 | 2.50 | |
| Rbl:p | 1.10 | 1.12 | 0.81 | 0.86 | |
| In vitro metabolic parameters | |||||
| Microsome parameters | |||||
| Vm (pmol/min per milligram protein) | 1310 | 4260 | n/a | 1070 | |
| Km (µM) | 0.44 | 1.54 | n/a | 0.625 | |
| Hepatocyte parameters | |||||
| Vm (pmol/min per 106 hepatocytes) | 627 | n/a | 132 | 283.8 | |
| Km (µM) | 3.4 | n/a | 0.8 | 1.08 | |
| Metabolic pathway in humans | |||||
| Clearance due to cytochromes | 85% | ||||
| Contribution of cytochromes | 97% due to CYP3A4 | ||||
| MBI parameters | |||||
| kinact (1/h) | 12.6 | ||||
| Kapp (µM) | 1.55 | ||||
| Induction parameters | |||||
| Ind max | 10.41 | ||||
| Ind C50 (µM) | 3.03 |
Ind C50, concentration at which there is a 50% maximal induction effect; Ind max, maximum induction; MBI, mechanism-based inhibition.