Pharmacokinetic parameters of (R)-RAB, (S)-RAB, and RAB thioether obtained after intravenous injection of (R)-RAB (3 mg/kg) in ABT-treated and control rats
Results are expressed as mean ± S.D. (n = 4). The em dashes indicate no value because of the lack of time points to calculate.
| Component | AUC0–t | AUC0–∞ | t1/2 | MRT |
|---|---|---|---|---|
| ng⋅h/ml | ng⋅h/ml | h | h | |
| (R)-RAB | ||||
| ABT | 2858 ± 325 | 2891 ± 354 | 0.273 ± 0.052 | 0.360 ± 0.008 |
| Control | 621 ± 72 | 621 ± 73 | 0.122 ± 0.009 | 0.165 ± 0.007 |
| Thioether | ||||
| ABT | 609 ± 146 | 610 ± 147 | 1.02 ± 0.08 | 1.55 ± 0.13 |
| Control | 50.8 ± 2.8 | 50.9 ± 2.8 | 1.01 ± 0.11 | 0.656 ± 0.043 |
| (S)-RAB | ||||
| ABT | 4.57 ± 1.10 | — | 0.913 ± 0.070 | 1.19 ± 0.08 |
| Control | 0.31 ± 0.08 | — | — | 0.159 ± 0.015 |
AUC0–∞, AUC from time 0 to infinity; MRT, mean residence time; t1/2, half-life.