TABLE 2

Methods and techniques used to study unbound drug concentration in the brain

Homogenize and DialyzePreclinical
MicrodialysisNormally preclinical
CSF samplingPreclinical and clinical
Displacement of tracer (PET scan)Preclinical and clinical
Biomarker of target occupancyPreclinical and clinical
  • PET, positron emission tomography.