TABLE 1

The pKa, log D, TPSA, and Vss values for a number of acidic, neutral, and basic drugs

DrugpKaLog D7.4TPSAVss
Å2l/kg
IndomethacinAcid 3.90.7680.29
KetoprofenAcid 4.20.2540.15
Fluconazole#0.5720.7
Isoniazid#−0.7650.6
Pyrazinamide#−0.7690.77
Diazepam#2.8331.1
ChlorpheniramineBasic 9.11.5163
FluoxetineBasic 10.51.42135
HydroxyzineBasic 7.83.93622.5
  • # , No significant ionisation under pH ranges encountered in body.