Fractional metabolism (fm) estimated using the P450 and UGT kinetic models
The fm values were calculated using CLint values (see Table 3). Data shown are parameter estimates and CV% of the estimates.
| Enzyme | THC | 11-OH-THC | 11-OH-THC |
|---|---|---|---|
| Depletion | Formation | Depletion | |
| CYP2C9 | 0.91 (0.4%) | 1.00 (fixed) | 0.15 (3.6%) |
| CYP3A | 0.00 (fixed) | 0.00 (fixed) | 0.18 (3.0%) |
| CYP2D6 | 0.09 (4.4%) | 0.00 (fixed) | 0.00 (fixed) |
| UGTs | 0.00 (fixed) | 0.00 (fixed) | 0.67 (12%) |