TABLE 1

Results for model fitting to MM-IL datasets with 5% error

All four models were fit to the all the datasets with different fumic. [I] values ranging from 0 to 10 μM (n = 8) were used.

Simulated DataParametersMM*
(Post Hoc)MM-IL (Concurrent)EII
(Post Hoc)aEII-IL
(Concurrent)
MM-IL fumic = 0.02; KI,u = 0.1 µM; kinact = 0.1 minKI,u0.13 ± 0.010.1 ± 0.01KI,u1 = 0.01 ± 0.001
KI,u2 = 0.11 ± 0.02KI,u1 = 0.08 ± 0.01KI,u2 = 8.66 ± 7.97
kinact0.12 ± 0.010.1 ± 0.010.023 ± 0.00360.12 ± 0.08
kinact/KI,u0.941.00kinact/KI,u1 = 3.47kinact/KI,u1 = 1.54
% Convergence1001001004
Average AICc−496−526−523−516
Average r20.9970.9980.9980.998
MM-IL fumic = 0.1; KI,u = 0.1 µM; kinact = 0.1 minKI,u0.14 ± 0.010.1 ± 0.01KI,u1 = 0.02 ± 0.002
KI,u2 = 0.13 ± 0.02KI,u1 = 0.1 ± 0.01KI,u2 = 7.92 ± 5.35
kinact0.12 ± 0.010.1 ± 0.0030.063 ± 0.0070.11 ± 0.01
kinact/KI,u0.861.00kinact/KI,u1 = 3.47kinact/KI,u1 = 1.13
% Convergence10010010058
Average AICc−499−579−575−578
Average r20.9930.9980.9980.998
MM-IL fumic = 0.5; KI,u = 0.1 µM; kinact = 0.1 minKI,u0.1 ± 0.010.1 ± 0.005KI,u1 = 0.08 ± 0.01KI,u1 = 0.1 ± 0.01
KI,u2 = 0.55 ± 0.15KI,u2 = 13.66 ± 6.68
kinact0.10 ± 0.0020.1 ± 0.0020.12 ± 0.010.11 ± 0.004
kinact/KI,u1.061.00kinact/KI,u1 = 1.57kinact/KI,u1 = 1.1
% Convergence1001005696
Average AICc−579−636−631−632
Average r20.9950.9980.9980.998
MM-IL fumic = 0.9; KI,u = 0.1 µM; kinact = 0.1 minKI,u0.1 ± 0.010.1 ± 0.01KI,u1 = 0.1 ± 0.01KI,u1 = 0.08 ± 0.003
KI,u2 = 43.51 ± 21.92KI,u2 = 10.27 ± 2.77
kinact0.10 ± 0.0010.1 ± 0.0010.11 ± 0.0020.10 ± 0.002
kinact/KI,u1.051.01kinact/KI,u1 = 1.07kinact/KI,u1 = 1.38
% Convergence1001003664
Average AICc−645−647−640−633
Average r20.9980.9980.9980.997
  • a KI,u was calculated as KI · fumic.