Results for model fitting of MM-IL and MM models to nondilution MM-IL or EII-IL datasets at fumic = 0.02
| Simulated with | Parameters | Concurrent | Post Hoca |
|---|---|---|---|
| MM-IL fumic = 0.02 KI,u = 0.1 kinact = 0.1 | KI,u | 0.1 ± 0.01 | 0.1 ± 0.01 |
| kinact | 0.1 ± 0.01 | 0.1 ± 0.01 | |
| kinact/KI,u | 1.00 | 1.00 | |
| EII-IL fumic = 0.02 KI,u1 = 0.1 KI,u2 = 1.0 kinact = 0.14 | KI,u | KI,u1 = 0.10 ± 0.009 KI,u2 = 1.00 ± 0.077 | KI,u1 = 0.096 ± 0.009 KI,u2 = 1.04 ± 0.080 |
| kinact | 0.14 ± 0.04 | 0.024 ± 0.002 | |
| kinact/KI,u | kinact/KI,u1 = 1.40 | kinact/KI,u1 = 2.38 |
↵a KI,u calculated as KI · fumic was parameterized.