TABLE 1

Pharmacokinetic parameters for orally administered niclosamide and its metabolites in wild-type and LCN mice

Data in Fig. 5 were used to calculate pharmacokinetic parameters, as described in Materials and Methods. The values represent means ± S.D., n = 5.

AnalyteStrainTmaxCmaxT1/2AUC0–24 hCL/F
NIChμMhnmol·h/mll/h per kilogram
Wild-type0.80 ± 0.271.18 ± 0.1712.2 ± 3.88.80 ± 2.1330.98 ± 15.35
LCN0.75 ± 0.710.76 ± 0.20a17.2 ± 5.15.90 ± 2.1845.67 ± 23.98
NIC-OHhArbitrary unithArbitrary unitArbitrary unit
Wild-type0.80 ± 0.270.75 ± 0.394.10 ± 1.953.52 ± 1.7793.20 ± 79.16
LCN1.00 ± 0.610.07 ± 0.03a6.31 ± 3.740.37 ± 0.19a847.6 ± 622.3b
NIC-GhArbitrary unithArbitrary unitArbitrary unit
Wild-type0.63 ± 0.250.59 ± 0.238.17 ± 3.702.70 ± 1.1262.44 ± 48.51
LCN0.50 ± 0.311.35 ± 0.41b10.4 ± 6.25.09 ± 0.85a31.50 ± 13.90
  • AUC, area under the curve; T1/2, half-life.

  • a P < 0.01, compared with corresponding wild-type group; Student’s t test.

  • b P < 0.05, compared with corresponding wild-type group; Student’s t test.