TABLE 1

Sex differences in protein abundance of transporters across species

ProteinHumanMonkeyDogRatMouse
SLC22A6/OAT1M > F *1.3M > F *3.2
SLC22A7/OAT2NCBLQM > F *1.6
SLC22A8/OAT3NCNCNC
SLC22A11/OAT4NCNCNC
SLCO4C1/OATP4C1NDNCNCNC
SLC22A1/OCT1BLQBLQNC
SLC22A2/OCT2NCM > F *1.4M > F *1.6
SLC22A4/OCTN1NCNCNC
SLC22A5/OCTN2NCM > F *1.4F > M *1.3
ABCB1/MDR1F > M *1.4M > F *1.6F > M *2.0
SLC47A1/MATE1NCNCNC
ABCG2/BCRPBLQBLQNCM > F *1.6
ABCC1/MRP1NDF > M *1.3
ABCC2/MRP2NCNCNC
ABCC3/MRP3NDNCF > M *1.1F > M *3.1
ABCC4/MRP4NCF > M *2.4
SLC5A2/SGLT2F > M *1.2
ATP1A1/Na+/K+-ATPaseNDF > M *1.3
  • ABCB, ATP-binding cassette subfamily B; ABCC, ATP-binding cassette subfamily C; ABCG, ATP-binding cassette superfamily G; BCRP, breast cancer resistance protein; BLQ, below limit of quantification; F, female; M, male; NC, peptide not conserved; Na+/K+-ATPase, sodium/potassium-transporting ATPase; ND, sex difference was not determined, data were obtained with pooled quality control samples; , no significant difference; *, fold difference.