Inhibition on bidirectional transepithelial transport of Exp3174 at 50 μM in Caco-2 cells
The concentrations of GF120918, KO-143, and quercetin were 10, 10, and 100 μM, respectively. Data are shown as the mean ± S.D. (n = 3).
| Papp (×10−8 cm/s) | ER | ||
|---|---|---|---|
| A to B | B to A | ||
| Exp3174 | 1.65 ± 0.57 | 43.5 ± 5.1 | 30.0 |
| Exp3174 + GF120918 | 1.29 ± 0.41 | 23.3 ± 5.4 | 21.5 |
| Exp3174 + KO-143 | 5.22 ± 3.19 | 18.5 ± 2.3 | 3.5 |
| Exp3174 + quercetin | 3.84 ± 1.05 | 12.5 ± 3.4 | 3.6 |