Pharmacokinetic parameter estimates describing CDF disposition in single-pass IPLs from WT and PCK rats. Data represent mean ± S.D. (n = 3). Statistically significant differences were based on nonoverlapping 95% CIs: *P < 0.05, WT vs PCK.
| Parameter | WT | PCK | ||||||
|---|---|---|---|---|---|---|---|---|
| Estimate | CV% | 2.5% CI | 97.5% CI | Estimate | CV% | 2.5% CI | 97.5% CI | |
| CLUP (ml/min) | 8.80 | 10.9 | 6.74 | 10.9 | 4.69* | 15.5 | 3.05 | 6.34 |
| KBL (min-1) | 0.0828 | 13.5 | 0.0588 | 0.107 | 0.162* | 10.3 | 0.125 | 0.200 |
| KBile (min-1) | 0.0506 | 12.5 | 0.0371 | 0.0641 | 0.00181* | 45.5 | 0 | 0.00367 |
| KLag,Bile (min-1) | NA | 0.136 | 23.8 | 0.0630 | 0.209 | |||
NA, not applicable. Cl, confidence interval.