Albumin and total protein binding in rats and humans
Binding capacity (Bmax) is expressed as nanomoles per milligram albumin or total protein. Disassociation constant (Kd) is expressed as micromolars. Significant differences between pyrethroids are indicated by different subscript letters. Data are mean ± S.D.; P < 0.05.
| Compound | Albumin | Total Protein | ||||||
|---|---|---|---|---|---|---|---|---|
| Rat | Human | Rat | Human | |||||
| Bmax | Kd | Bmax | Kd | Bmax | Kd | Bmax | Kd | |
| nmol/mg | µM | nmol/mg | µM | nmol/mg | µM | nmol/mg | µM | |
| DLM | 2.6 ± 0.1a,* | 3.8 ± 0.3a | 4.0 ± 0.1a,* | 4.6 ± 0.3a | 3.4 ± 0.4a,* | 6.4 ± 0.5a | 4.1 ± 0.1a | 6.7 ± 0.7a |
| CIS | 3.2 ± 0.7 a,b,* | 10.3 ± 4.2b | 4.5 ± 0.2b | 7.7 ± 1.4b | 3.7 ± 0.4a,* | 12.4 ± 2.6b | 4.7 ± 0.2b | 10.4 ± 1.5b,c |
| TRANS | 4.1 ± 0.7b,c,* | 8.1 ± 2.8b | 4.9 ± 0.1c | 6.4 ± 0.6b | 4.5 ± 0.1b,* | 11.3 ± 0.3b,* | 5.2 ± 0.3b | 7.3 ± 1.3a,c |
↵* Denotes significant difference from corresponding human value.