Dosing Route | Dose | Component | Cmaxa | Tmax | t1/2 | AUCb |
---|---|---|---|---|---|---|
mg/kg | µg/ml | h | h | µg·h/ml | ||
Subcutaneous | 1 | Total radioactivity | 0.710 | 1.0 | 0.9 | 1.914 (100.0) |
TAK-448 | 0.334 | 1.0 | 1.0 | 0.832 (43.5) | ||
M-I | 0.284 | 1.0 | 0.9 | 0.737 (38.5) | ||
Subcutaneous | 10 | Total radioactivity | 4.739 | 1.0 | 1.4 | 19.103 (100.0) |
TAK-448 | 1.594 | 2.0 | 1.6 | 5.562 (29.1) | ||
M-I | 2.922 | 1.0 | 1.6 | 10.524 (55.1) | ||
Intravenous | 1 | Total radioactivity | 1.971 | — | 0.6 | 2.251 (100.0) |
TAK-448 | 1.649 | — | 0.5 | 1.615 (71.7) | ||
M-I | 0.152 | 0.5 | 0.9 | 0.268 (11.9) |