TABLE 3

Pharmacokinetic parameters of total radioactivity, TAK-448, and M-I in the plasma of rats after coadministration of [¹⁴C]TAK-448 and protease inhibitor cocktail

Parameters for total radioactivity are calculated from the mean plasma concentrations for three animals. Parameters for TAK-448 and M-I are calculated from the concentrations for the pooled samples from three animals. Numbers in parentheses denote percentage of total radioactivity. Data are taken from Fig. 4.

Dosing Route	Dose	Component	C_max^{^a}	T_max	t_1/2	AUC^{^b}
	mg/kg		µg/ml	h	h	µg·h/ml
Subcutaneous	1	Total radioactivity	0.710	1.0	0.9	1.914 (100.0)
		TAK-448	0.334	1.0	1.0	0.832 (43.5)
		M-I	0.284	1.0	0.9	0.737 (38.5)
Subcutaneous	10	Total radioactivity	4.739	1.0	1.4	19.103 (100.0)
		TAK-448	1.594	2.0	1.6	5.562 (29.1)
		M-I	2.922	1.0	1.6	10.524 (55.1)
Intravenous	1	Total radioactivity	1.971	—	0.6	2.251 (100.0)
		TAK-448	1.649	—	0.5	1.615 (71.7)
		M-I	0.152	0.5	0.9	0.268 (11.9)

T_max, time to reach C_max.
↵^a C_max of total radioactivity and TAK-448 after intravenous administration denotes the concentration at 5 minutes after administration.
↵^b 0-24h