TABLE 1

Summary of DCF pharmacokinetic parameters in plasma of WT and KO mice after a single 3- or 10-mg/kg-DCF dose

Parameters of C0, t1/2, and AUC0-tlast were calculated using noncompartmental analysis. Each value represents the mean ± S.E.M. of five to seven subjects/group.

GenotypeC0t1/2AUC0-tlast
µMminµM × min
3 mg/kg
 C57 WT57.8 ± 6.031.2 ± 4.01050 ± 50
 C57 BCRP KO46.0 ± 5.127.8 ± 3.61020 ± 80
10 mg/kg
 C57 WT132 ± 830.5 ± 3.13420 ± 290
 C57 BCRP KO201 ± 4433.5 ± 2.53570 ± 340
3 mg/kg
 FVB WT51.4 ± 5.124.0 ± 4.1862 ± 86
 FVB Mrp3 KO41.2 ± 3.337.5 ± 9.21110 ± 130
10 mg/kg
 FVB WT178 ± 1637.8 ± 5.64220 ± 420
 FVB Mrp3 KO172 ± 1352.9 ± 9.84770 ± 280
  • AUC0-tlast, from time 0 to the last measurable concentration.