TABLE 2

Summary of in vitro DCF metabolism in mouse models

Metabolic parameters were determined using S9 fraction from FVB and C57 strains of mice that were WT or KO for Mrp3. Data represent the mean ± S.E.M. from two separate studies.

GenotypeVmaxKmMetabolic CLint
pmol/min/mgµMµl/min/mg
C57 WT846 ± 3169.3 ± 4.312.2
C57 KO882 ± 2682.4 ± 1.110.7
FVB WT734 ± 3244.3 ± 3.516.7
FVB KO696 ± 7943.3 ± 9.016.4
  • CLint, intrinsic uptake clearance.