O-OH-Ator | | | | | | |
Vmax (pmol/min per 106 cells) | 111.5 ± 15.42 | 93.66 ± 8.19 | 99.83 ± 3.33*,# | 60.28 ± 5.55 | 72.05 ± 4.78 | 93.25 ± 7.93**,## |
Km (μM) | 53.8 ± 12.1 | 24.13 ± 4.55 | 7.5 ± 0.79**,## | 8.31 ± 2.34 | 7.29 ± 1.54 | 5.51 ± 1.62**,## |
CLint (μl/min per 106 cells) | 2.07 ± 0.31 | 3.88 ± 0.32 | 13.31 ± 0.17**,## | 7.25 ± 0.42 | 9.88 ± 0.51 | 16.92 ± 0.23**,## |
P-OH-Ator | | | | | | |
Vmax (pmol/min per 106 cells) | 23.48 ± 2.31 | 29.27 ± 1.77 | 43.41 ± 1.02**,## | 29.38 ± 2.33 | 37.44 ± 2.99 | 48.78 ± 1.52**,## |
Km (μM) | 10.14 ± 2.87 | 7.51 ± 1.43 | 5.52 ± 0.44*,# | 4.98 ± 1.38 | 5.14 ± 1.43 | 3.21 ± 1.38**,## |
CLint (μl/min per 106 cells) | 2.31 ± 0.25 | 3.89 ± 0.31 | 7.86 ± 0.62**,## | 5.91 ± 0.27 | 6.92 ± 0.34 | 15.19 ± 0.51**,## |
Atorvastatin uptake | | | | | | |
Vmax (pmol/min per 106 cells) | 396.84 ± 32.75 | 375.5 ± 11.75 | 660.69 ± 10.18**,## | 342.79 ± 5.88 | 387.88 ± 8.63 | 731.85 ± 39.39**,## |
Km (μM) | 6.81 ± 0.79 | 3.41 ± 0.23** | 4.7 ± 0.16**,## | 4.18 ± 0.2 | 3.23 ± 0.07 | 5.22 ± 0.43**,## |
CLup,int,Pas (μl/min per 106 cells) | 5.7 ± 1.63 | 7.58 ± 0.26 | 9.48 ± 2.22 | 6.23 ± 2.14 | 7.79 ± 1.2 | 8.1 ± 1.86 |
CLup,int,active (μl/min per 106 cells) | 58.43 ± 2.22 | 110.32 ± 4.03** | 140.81 ± 3.3**,## | 82.14 ± 2.84 | 120.04 ± 2.08** | 140.74 ± 8.51**,## |
CLint,uptake (μl/min per 106 cells) | 64.12 ± 2.84 | 117.9 ± 4.29** | 150.28 ± 3.52**,## | 88.37 ± 2.98 | 127.82 ± 2.28** | 148.84 ± 9.37**,## |