TABLE 4

The estimated and observed parameters of Ator in intestine and hepatocytes of 10-day diabetes mellitus (DM), 22-day DM, high-fat diet (HFD), and control (CON) rats

Parameters	10-day			22-day
	CON	HFD	DM	CON	HFD	DM
Intestinal transport
RE_Oatp1a5^{^a}	1.00	0.86 ± 0.13	0.38 ± 0.13	1.00	1.48 ± 0.24	0.54 ± 0.20
RE_{g P-p}^{^a}	1.00	0.79 ± 0.12	0.40 ± 0.13	1.00	0.76 ± 0.20	0.46 ± 0.21
RE_Bcrp^{^a}	1.00	0.98 ± 0.12	0.33 ± 0.14	1.00	1.21 ± 0.20	1.45 ± 0.21
P_eff,Pas (×10⁻³cm/min)	11.95	11.95	11.95	12.02	12.02	12.02
P_eff,Oatp1a5 (×10⁻³cm/min)^{^b}	0.80	0.69 ± 0.10	0.30 ± 0.10	0.77	1.14 ± 0.18	0.42 ± 0.15
P_eff,P-gp (×10⁻³cm/min)^{^b}	2.15	1.70 ± 0.26	0.86 ± 0.26	2.18	1.66 ± 0.44	1.00 ± 0.46
P_eff,Bcrp (×10⁻³cm/min)^{^b}	6.65	6.52 ± 0.79	2.19 ± 0.93	6.68	8.08 ± 1.34	9.69 ± 1.40
Pred P_eff (×10⁻³cm/min)^{^c}	—	4.42 ± 1.21	9.20 ± 1.32	—	3.42 ± 1.35	1.75 ± 1.37
Obs P_eff (×10⁻³cm/min)^{^d}	3.95 ± 0.67	4.81 ± 0.46	7.16^**^,^##±0.72	3.92 ± 0.77	5.34 ± 0.83	1.53^**^,^##±0.82
Hepatic uptake
RE_Oatp1b2^{^a}	1	1.51 ± 0.20	1.97 ± 0.26	1	1.07 ± 0.25	1.93 ± 0.23
CL_up,int,Pas (μl/min per 10⁶ cells)	5.69	5.69	5.69	6.13	6.13	6.13
Pred CL_{up,int, Oatp1b2} (μl/min per 10⁶ cells)^{^b}	58.42	87.63 ± 11.68	115.09 ± 15.19	82.13	87.88 ± 20.53	158.51 ± 18.89
Pred CL_up,int (μl/min per 10⁶ cells)^{^e}	—	93.32 ± 11.71	120.78 ± 16.11	—	94.01 ± 21.32	164.64 ± 22.13
Obs CL_up,int (μl/min per 10⁶ cells)^{^d}	64.12 ± 2.84	117.9 ± 4.29^**	150.28 ± 3.52^**^,^##	88.37 ± 2.98	127.82 ± 2.28^**	148.84 ± 9.37^**^,^##

↵^a Pred, predicted; RE, relatve expression of protein to CON rats.
↵^b P_eff,i (/or CL_up,i) = P_eff,i (/or CL_up,i) in normal rats × RE.
↵^c Pred P_eff = P_eff,Pas + P_eff,Oatp1a5 − P_eff,P-gp − P_eff,Bcrp.
↵^d Data are expressed as mean ± S.D. (n = 5) of CON, HFD, and DM rats.
↵^e Pred CL_up,int = CL_up,int,Pas + CL_{up,int,Oatp1b2}.
↵* P < 0.05; **P < 0.01 vs. CON rats; ^#P < 0.05; ^##P < 0.01 vs. HFD rats.