TABLE 1
Glossary of the terms used in model equations
| Parameter | Description | Unit |
|---|---|---|
| X1, X2 | Amount of drug in central and peripheral compartments | nmol |
| C1, C2 | Concentration of drug in central and peripheral compartments | nM |
| C3 | Concentration of drug in tumor interstitium | nM |
| C4 | Concentration of cell surface drug-antigen complex | nM |
| V1, V2 | Volume of the central, peripheral compartment | l |
| Ctumor | Tumor concentration of the drug | nM |
| CLD | Distribution clearance | l/h |
| CL | Systemic clearance | l/h |
| TV | Tumor volume | mm3 |
| Rcap | Radius of tumor blood capillary | µm |
| Rk | Average distance between two capillaries | µm |
| Rt | Tumor radius | Cm |
 | Void fraction | Unitless |
| D | Diffusion coefficient | cm2/h |
| P | Permeability | µm/h |
| kon | Association rate between drugs and human epidermal growth factor receptor 2 (HER2) | 1/nM per hour |
| KD | Dissociation constant between drugs and HER2 | pM |
| koff | Dissociation rate between drugs and HER2 | 1/h |
| kint | Internalization rate of the drug-antigen complex | 1/h |
 | Total HER2 concentration on N87 cells | nM |
 | Total HER2 concentration on MDA-MB-468 cells | nM |