TABLE 2
Model parameter values
| Parameter | Value | Unit | Source |
|---|---|---|---|
| Rcap | 8 | µm | From Schmidt and Wittrup (2009), Shah et al. (2012) |
| Rk | 75 | µm | From Schmidt and Wittrup (2009), Shah et al. (2012) |
| Rt | 0.42 | cm | Measured |
 | 0.24 | unitless | From Shah et al. (2012) |
| TV | 300 | mm3 | Measured |
| kon | 0.259 | 1/nM per hour | From Shah et al. (2012) |
| KD_trastuzumab | 90 | pM | Measured |
| KD_F(ab)2 | 42 | pM | Measured |
| KD_Fab | 548 | pM | Measured |
| KD_scFv | 503 | pM | Measured |
| koff_ trastuzumab | 0.023 | 1/h | Calculated |
| koff_ F(ab)2 | 0.011 | 1/h | Calculated |
| koff_ Fab | 0.14 | 1/h | Calculated |
| koff_ scFv | 0.13 | 1/h | Calculated |
| kint | 0.035 | 1/h | From Maass et al. (2016) |
 | 426 | nM | Measured |
 | 0 | nM | Assumed |