TABLE 2

Model parameter values

ParameterValueUnitSource
Rcap8µmFrom Schmidt and Wittrup (2009), Shah et al. (2012)
Rk75µmFrom Schmidt and Wittrup (2009), Shah et al. (2012)
Rt0.42cmMeasured
Embedded Image0.24unitlessFrom Shah et al. (2012)
TV300mm3Measured
kon0.2591/nM per hourFrom Shah et al. (2012)
KD_trastuzumab90pMMeasured
KD_F(ab)242pMMeasured
KD_Fab548pMMeasured
KD_scFv503pMMeasured
koff_ trastuzumab0.0231/hCalculated
koff_ F(ab)20.0111/hCalculated
koff_ Fab0.141/hCalculated
koff_ scFv0.131/hCalculated
kint0.0351/hFrom Maass et al. (2016)
Embedded Image426nMMeasured
Embedded Image0nMAssumed